This project was funded in part through NSF CCLI A&I Grant number DUE-0087638 and in part through the Susquehanna University Summer Research Partners Program

 

 

Workshop Genetics Syllabus, Fall 2009

 

 

Section One: Dr. Tammy Tobin (MWF)

Office: 238 Fisher Hall

Phone: 4067

Office Hours: M,W 12:00 - 1:00 p.m., T, Th 3 - 4 pm.

SN: Tammytobinjanzen

Email: tobinjan@susqu.edu

Facebook: tobinjan

 

Section Two: Dr. Tom Peeler (T,Th)

Office: 246 Fisher Hall

Phone: 4381

Office Hours: TBA

Email: peelert@susqu.edu

 

 

Student Learning Objectives: As a result of taking this course, students will:

1) Be able to describe and apply important concepts and theories in genetics.

2) Show evidence of expanded information literacy in biology.

3) Acquire and demonstrate basic skills with genetics laboratory equipment and techniques.

4) Learn to work more effectively in groups. In particular, students will demonstrate processes needed for a positive working relationship with team members, demonstrate and evaluate the roles and functions of leadership and team membership, and work together as a team to analyze and solve problems.

5) Be able to analyze genetic diversity in human populations, and to articulate how that diversity underlies and impacts concepts such as sex, gender and race.

6) Recognize and understand the diversities of human experiences with respect to the gathering and use of genetic knowledge.

7) Improve their ability to ask and answer scientific questions.

Grading Policy: The final class grade will be based on three in-class exams (45%), graded in-class assignments (15%), Readiness Assurance Process (RAP) quizzes (10%), and investigative laboratory reports (30%). Grades will be based on the table below. There is no curve.

 

Percent Grade
Letter Grade
94
A
90
A-
87
B+
84
B
80
B-
77
C+
74
C
70
C-
67
D+
64
D
60
D-
<60
F

 

Textbook: Introduction to Genetic Analysis, 9th Edition. Anthony J.F. Griffiths, Susan R. Wessler, Richard C. Lewontin, Sean B. Carroll. ISBN 0-7167-6887-9.

Rules: Class attendance is mandatory, and you will receive a zero for any graded class work that you miss because of an absence. If you know that you will miss a scheduled activity, please talk to your professor in advance. Note that we do not promise that you will be able to make up all assignments, but your chances are vastly improved if you talk to us early, and we will try to work with you to the extent that we can.

There will be no food, drink, gum or other consumables allowed in the laboratory. This is a Federal law, and also good laboratory practice. (In general, mistakenly eating your experiments is less productive than keeping them in your test tubes.) We will have a table outside the classroom that can be used to hold food/drink items for use during class time.

Accommodations: If you have a documented learning disability, bring the paperwork from Disability Services to your professor's office. We will be happy to make any arrangements necessary to make this course work for you.

Schedule of Events: In the table below, you will see the events that are scheduled for workshop genetics this semester. The timing of some events may change to accommodate the realities of life in science (somehow everything always takes longer than we think it will!), but test dates will normally not change.

Topic: This section shows the topics of the week, and the reading assignments that you are expected to read prior to that week. RAPs and activities will be based on the background readings and assignments, so make sure you are prepared for each class.

Handouts: These are the handouts that you will need to bring with you for each of the topics. Some of the handouts can also be accessed from topic or module mystery web pages, but you can always access them all from the schedule.

Assignments: Lists any homework assignments that will be associated with each topic. Your instructor will tell you the exact due dates for each assignment.

 

Week/Dates Topic Handouts Assignments

Week 1

8/31-9/4

Introduction to Workshop Genetics

Printer-Friendly Version of the Syllabus

Printer-Friendly Version of the Schedule

 

Introduction to Team-Based Learning Introduction to Team-Based Learning Practice RAP

Genetics Concepts: Single-Gene Inheritance

Read: Chapter 2, pages 31-42

Single Gene Inheritance

Section One Notes

Team Application Problems: Single-Gene Inheritance

The Case of the Confused Counselor - Introduction

Read: The Case of the Confused Counselor Module Mystery

Pre-Class Assignment Bring Your Completed Pre-Class Assignment to Class

Week 2

9/7-9/11

Genetics Concepts: The Chromosomal and Molecular Basis of Single Gene Inheritance Patterns

Read: Chapter 2, pages 42-57 (omit single gene inheritance in haploids)

Mitosis and Meiosis

Section One Notes

RAP 1

Genetics Skills: Mitosis and the Microscopic Analysis of Human Chromosome Spreads

Read: Human Chromosome Spreads Procedure

Human Chromosome Spreads Procedure

Take pictures of chromosome spreads

Genetics Concepts: Discovering Genes by Observing Segregation Ratios

Read: Chapter 2, pages 57-75

Observing Segregation Ratios

Section One Notes

Team Application Problems: Discovering Genes by Observing Segregation Ratios

Week 3

9/14-9/18

The Case of the Confused Counselor - Generating a Family Tree

Read: American Medical Association Family History

The Family Medical History in Disease Prevention

Turn in Family Genetic History Questionnaire

Genetics and Diversity: Power, Privilege, and the Use of Genetic Information

Read: Genetic Determinism and Discrimination

Genetic Determinism and Discrimination Complete Use of Genetic Information Reflection, Due Date TBA

Genetics Skills: Flourescence Microscopy and Mitosis

Read: Fluorescence Microscopy Lab Handouts

Fluorescence Microscopy Lab Handouts Take Pictures of Fluorescently-labeled Mitotic Cells

The Biology Portfolio

Read: The Sharepoint Portfolio

How to Develop Your Sharepoint Portfolio Place Photographs in Portfolio - Laboratory Skills Section

The Case of the Confused Counselor - Generating a Molecular Pedigree

Read: Molecular Pedigrees Laboratory Procedure Handout

Molecular Pedigrees Laboratory Procedure Handout

Experimental Design Sheet

Get Peer Review, and Turn in Experimental Design Sheet

Week 4

9/21-9/25

Genetics Concepts: Independent Assortment of Genes

Read: Text Chapter 3, pages 89-97 (Stop at end of Predicting Progeny Ratios)

Independent Assortment of Genes

Section One Handout

RAP 2

 

Biological Information Literacy: How to find and use high quality scientific references.

Read: Critically Analyzing Information Sources

Information Literacy 101: Finding Quality Background References

Rubric for Assessing Biological Information Literacy

Information Literacy Worksheet.

Biology Skills: Proper Use of Micropipettes

Read: Oxford Benchmate Operating Instructions

Oxford Benchmate Operating Instructions

Micropipet Competency Skills Check Sheet

Complete Micropipet Competency Skills Check Sheet
The Case of the Confused Counselor - Generating and Analyzing Molecular Pedigree Data Molecular Pedigrees Laboratory Procedure Handout  

Week 5

9/28-10/2

Test #1

Test 1 Review Questions

Section One, Part 1

Test 1, 2008

Test 1, 2007

 

Test #1

Biology Information Literacy/Skills: How to Prepare Professional Poster Presentations

Read: WebGURU "Preparing a Poster Presentation"

Poster Presentation Guidelines  
Poster Teamwork Time   Email completed posters to your professor

Week 6

10/5-10/9

The Case of the Confused Counselor Poster Presentations

Peer Review of Posters

Poster Presentations

Biology Teamwork: Assessing Contributions of Team Members

Assessing the Contributions of Your Team Members

Evaluating Team Members Rubric

Place Poster in Portfolio Oral Communication Skills Folder

Genetics Concepts: Independent Assortment and Recombination

Read: Text Chapter 3, pages 97-109

Independent Assortment and Recombination

Section One Notes

Team Application Problems: Recombination

Week 7

10/12-10/16

Genetics Concepts: Mapping Eukaryotic Chromosomes by Recombination

Read: Text Chapter 4, pages 129-139

 

 

RAP 3

Genetics Concepts: Gene Mapping and Chi Square Analysis

Read: Text Chapter 4, pages 140-157

Mapping Eukaryotic Chromosomes by Recombination

Section One Notes, part One

Section One Notes, Part Two

Team Application Problems: Mapping Eukaryotic Chromosomes by Recombination

Week 8

10/19-10/23

Fall Break M, T

Fall Break

Fall Break

DNA Structure and The Phenotypic Consequences of Mutations

Read Text Chapter 7, pages 269-275 and Chapter 15, pages 513-518

DNA Structure and Mutations

 

RAP 4

The Case of the Cafeteria Calamity - Introduction and Experimental Design

Read: The Case of the Cafeteria Calamity Background and Pre-Lab Activity

Read: ERes Articles

The Case of the Cafeteria Calamity Pre-Lab Activity

The Case of the Cafeteria Calamity Procedure

Experimental Design Sheet

Turn in Pre-Lab Activity

Turn in Experimental Design Sheet

Week 9

10/26-10/30

The Case of the Cafeteria Calamity - Setting up Yeast Cultures

The Case of the Cafeteria Calamity Procedure

 

Genetics Concepts: Gene Interactions

Read: Text Chapter 6, pages 221-249

Gene Interactions

Section One Notes

 

Genetics and Diversity: Sex, Gender and Sexual Orientation

Read: WHO Gender and Genetics

  Team Application Problems: Gene Interactions and Diversity

Week 10

11/2-11/6

Test #2

Test #2 Review Questions

Test #2

The Case of the Cafeteria Calamity - Analyzing and Interpreting your Yeast Experiments    
Poster Teamwork Time   Email Posters to Instructor

Week 11

11/9-11/13

The Case of the Cafeteria Calamity Poster Presentations

Peer Review of Posters

Poster Presentations

Genetics Teamwork: Assessment of Contributions of Team Members

 

Assessing the Contributions of Your Team Members

Team Evaluation Rubric

Place Poster in Portfolio Oral Communication Skills Folder

The Case of the Reclusive Relative - Background and Pre-Class Assignment

Read: The Case of the Reclusive Relative Background Activity

Read Chapter 3, pages 112-118

Reclusive Relative Background Activity Bring Completed Reclusive Relative Background Activity
Video: "The Journey of Man"    

Genetics and Diversity: The Genetics of 'Race'.

Read: Genetic Variation, Classification and 'Race'

Genetic Variation, Classification and 'Race' Get Final Diversity Paper Topic
     

Week 12

11/16-11/20

Genetics Concepts: The Polymerase Chain Reaction and DNA Sequencing

Read Text Chapter 20, pages 231-235

PCR and Sequencing

Section One Notes

Team Application Problems: Advanced Applications of DNA Sequencing
The Case of the Reclusive Relative - Amplifying the Mitochondrial Control Region Using PCR

Isolating DNA from Cheek Cells Procedure

Amplifying the Mitochondrial Control Region Procedure

 

Basic Genetics Concepts: Population Genetics

Read: Text Chapter 17, pages 603-615

Population Genetics

RAP 5

Begin Team Application Problems - Population and Evolutionary Genetics

Week 13

11/23-11/27

The Case of the Reclusive Relative - Sequencing the Mitochondrial Control Region

Sequencing Procedure  

Genetics Concepts: The Effect of Sexual Reproduction on Variation

Read: Text Chapter 17, pages 615-620

  Continue Team Application Problems: Population and Evolutionary Genetics
Thanksgiving Break Wednesday - Friday    

Week 14

11/30-12/4

The Case of the Reclusive Relative - Analyzing Sequence Data

 

 

Genetics Concepts: Sources of Variation - Mutation and Migration

Read Chapter 17, pages 620-623

Sources of Variation

Section One Handout

 

Genetics Concepts: Sources of Variation - Selection and Random Events

Read Chapter 17, pages 623-633

Selection and Random Events

Section One Handout

Complete Team Application Problems: Population and Evolutionary Genetics
Genetics and Diversity   Final Diversity Reflection Paper Due as Announced by Professor

Week 15

12/7-12/11

The Case of the Reclusive Relative Poster Presentations

Posters cancelled

 

 

Peer Review of Posters

 

 

Poster Presentations

Cancelled

Genetics Teamwork: Assessment of Contributions of Team Members, Course Assessment Assessing the Contributions of Your Team Members Place Poster in Portfolio Oral Communication Skills Folder
Genetics Concepts: Phylogenetic Analysis and MacClade

Phylogenetic Analysis Using BLAST, CLC, Clustal and MacClade Analysis

Mitochondrial FASTA sequences

Mitochondrial NBRF Sequences

Team Application Problems - Phyogenetic Analysis and MacClade
Test #3 Test #3 Will Be Held During the Scheduled Final Exam Time

Population Genetics Review Questions

Population Genetics Review Answers

Molecular Evolution Review Questions

Molecular Evolution Review Answers

Test #3