Workshop Syllabus

This project was funded in part through NSF CCLI A&I Grant number DUE-0087638 and in part through the Susquehanna University Summer Research Partners Program

Workshop Genetics Syllabus, Fall 2009

Section One: Dr. Tammy Tobin (MWF)

Office: 238 Fisher Hall

Phone: 4067

Office Hours: M,W 12:00 - 1:00 p.m., T, Th 3 - 4 pm.

SN: Tammytobinjanzen

Email: tobinjan@susqu.edu

Facebook: tobinjan

Section Two: Dr. Tom Peeler (T,Th)

Office: 246 Fisher Hall

Phone: 4381

Office Hours: TBA

Email: peelert@susqu.edu

Student Learning Objectives: As a result of taking this course, students will:

1) Be able to describe and apply important concepts and theories in genetics.

2) Show evidence of expanded information literacy in biology.

3) Acquire and demonstrate basic skills with genetics laboratory equipment and techniques.

4) Learn to work more effectively in groups. In particular, students will demonstrate processes needed for a positive working relationship with team members, demonstrate and evaluate the roles and functions of leadership and team membership, and work together as a team to analyze and solve problems.

5) Be able to analyze genetic diversity in human populations, and to articulate how that diversity underlies and impacts concepts such as sex, gender and race.

6) Recognize and understand the diversities of human experiences with respect to the gathering and use of genetic knowledge.

7) Improve their ability to ask and answer scientific questions.

Grading Policy: The final class grade will be based on three in-class exams (45%), graded in-class assignments (15%), Readiness Assurance Process (RAP) quizzes (10%), and investigative laboratory reports (30%). Grades will be based on the table below. There is no curve.

Percent Grade	Letter Grade
94	A
90	A-
87	B+
84	B
80	B-
77	C+
74	C
70	C-
67	D+
64	D
60	D-
<60	F

Textbook: Introduction to Genetic Analysis, 9th Edition. Anthony J.F. Griffiths, Susan R. Wessler, Richard C. Lewontin, Sean B. Carroll. ISBN 0-7167-6887-9.

Rules: Class attendance is mandatory, and you will receive a zero for any graded class work that you miss because of an absence. If you know that you will miss a scheduled activity, please talk to your professor in advance. Note that we do not promise that you will be able to make up all assignments, but your chances are vastly improved if you talk to us early, and we will try to work with you to the extent that we can.

There will be no food, drink, gum or other consumables allowed in the laboratory. This is a Federal law, and also good laboratory practice. (In general, mistakenly eating your experiments is less productive than keeping them in your test tubes.) We will have a table outside the classroom that can be used to hold food/drink items for use during class time.

Accommodations: If you have a documented learning disability, bring the paperwork from Disability Services to your professor's office. We will be happy to make any arrangements necessary to make this course work for you.

Schedule of Events: In the table below, you will see the events that are scheduled for workshop genetics this semester. The timing of some events may change to accommodate the realities of life in science (somehow everything always takes longer than we think it will!), but test dates will normally not change.

Topic: This section shows the topics of the week, and the reading assignments that you are expected to read prior to that week. RAPs and activities will be based on the background readings and assignments, so make sure you are prepared for each class.

Handouts: These are the handouts that you will need to bring with you for each of the topics. Some of the handouts can also be accessed from topic or module mystery web pages, but you can always access them all from the schedule.

Assignments: Lists any homework assignments that will be associated with each topic. Your instructor will tell you the exact due dates for each assignment.

Week/Dates	Topic	Handouts	Assignments
Week 1 8/31-9/4	Introduction to Workshop Genetics	Printer-Friendly Version of the Syllabus Printer-Friendly Version of the Schedule
	Introduction to Team-Based Learning	Introduction to Team-Based Learning	Practice RAP
	Genetics Concepts: Single-Gene Inheritance Read: Chapter 2, pages 31-42	Single Gene Inheritance Section One Notes	Team Application Problems: Single-Gene Inheritance
	The Case of the Confused Counselor - Introduction Read: The Case of the Confused Counselor Module Mystery	Pre-Class Assignment	Bring Your Completed Pre-Class Assignment to Class
Week 2 9/7-9/11	Genetics Concepts: The Chromosomal and Molecular Basis of Single Gene Inheritance Patterns Read: Chapter 2, pages 42-57 (omit single gene inheritance in haploids)	Mitosis and Meiosis Section One Notes	RAP 1
	Genetics Skills: Mitosis and the Microscopic Analysis of Human Chromosome Spreads Read: Human Chromosome Spreads Procedure	Human Chromosome Spreads Procedure	Take pictures of chromosome spreads
	Genetics Concepts: Discovering Genes by Observing Segregation Ratios Read: Chapter 2, pages 57-75	Observing Segregation Ratios Section One Notes	Team Application Problems: Discovering Genes by Observing Segregation Ratios
Week 3 9/14-9/18	The Case of the Confused Counselor - Generating a Family Tree Read: American Medical Association Family History	The Family Medical History in Disease Prevention	Turn in Family Genetic History Questionnaire
	Genetics and Diversity: Power, Privilege, and the Use of Genetic Information Read: Genetic Determinism and Discrimination	Genetic Determinism and Discrimination	Complete Use of Genetic Information Reflection, Due Date TBA
	Genetics Skills: Flourescence Microscopy and Mitosis Read: Fluorescence Microscopy Lab Handouts	Fluorescence Microscopy Lab Handouts	Take Pictures of Fluorescently-labeled Mitotic Cells
	The Biology Portfolio Read: The Sharepoint Portfolio	How to Develop Your Sharepoint Portfolio	Place Photographs in Portfolio - Laboratory Skills Section
	The Case of the Confused Counselor - Generating a Molecular Pedigree Read: Molecular Pedigrees Laboratory Procedure Handout	Molecular Pedigrees Laboratory Procedure Handout Experimental Design Sheet	Get Peer Review, and Turn in Experimental Design Sheet
Week 4 9/21-9/25	Genetics Concepts: Independent Assortment of Genes Read: Text Chapter 3, pages 89-97 (Stop at end of Predicting Progeny Ratios)	Independent Assortment of Genes Section One Handout	RAP 2
	Biological Information Literacy: How to find and use high quality scientific references. Read: Critically Analyzing Information Sources	Information Literacy 101: Finding Quality Background References Rubric for Assessing Biological Information Literacy	Information Literacy Worksheet.
	Biology Skills: Proper Use of Micropipettes Read: Oxford Benchmate Operating Instructions	Oxford Benchmate Operating Instructions Micropipet Competency Skills Check Sheet	Complete Micropipet Competency Skills Check Sheet
	The Case of the Confused Counselor - Generating and Analyzing Molecular Pedigree Data	Molecular Pedigrees Laboratory Procedure Handout
Week 5 9/28-10/2	Test #1	Test 1 Review Questions Section One, Part 1 Test 1, 2008 Test 1, 2007	Test #1
	Biology Information Literacy/Skills: How to Prepare Professional Poster Presentations Read: WebGURU "Preparing a Poster Presentation"	Poster Presentation Guidelines
	Poster Teamwork Time		Email completed posters to your professor
Week 6 10/5-10/9	The Case of the Confused Counselor Poster Presentations	Peer Review of Posters	Poster Presentations
	Biology Teamwork: Assessing Contributions of Team Members	Assessing the Contributions of Your Team Members Evaluating Team Members Rubric	Place Poster in Portfolio Oral Communication Skills Folder
	Genetics Concepts: Independent Assortment and Recombination Read: Text Chapter 3, pages 97-109	Independent Assortment and Recombination Section One Notes	Team Application Problems: Recombination
Week 7 10/12-10/16	Genetics Concepts: Mapping Eukaryotic Chromosomes by Recombination Read: Text Chapter 4, pages 129-139		RAP 3
Week 7 10/12-10/16	Genetics Concepts: Gene Mapping and Chi Square Analysis Read: Text Chapter 4, pages 140-157	Mapping Eukaryotic Chromosomes by Recombination Section One Notes, part One Section One Notes, Part Two	Team Application Problems: Mapping Eukaryotic Chromosomes by Recombination
Week 8 10/19-10/23	Fall Break M, T	Fall Break	Fall Break
	DNA Structure and The Phenotypic Consequences of Mutations Read Text Chapter 7, pages 269-275 and Chapter 15, pages 513-518	DNA Structure and Mutations	RAP 4
	The Case of the Cafeteria Calamity - Introduction and Experimental Design Read: The Case of the Cafeteria Calamity Background and Pre-Lab Activity Read: ERes Articles	The Case of the Cafeteria Calamity Pre-Lab Activity The Case of the Cafeteria Calamity Procedure Experimental Design Sheet	Turn in Pre-Lab Activity Turn in Experimental Design Sheet
Week 9 10/26-10/30	The Case of the Cafeteria Calamity - Setting up Yeast Cultures	The Case of the Cafeteria Calamity Procedure
	Genetics Concepts: Gene Interactions Read: Text Chapter 6, pages 221-249	Gene Interactions Section One Notes
	Genetics and Diversity: Sex, Gender and Sexual Orientation Read: WHO Gender and Genetics		Team Application Problems: Gene Interactions and Diversity
Week 10 11/2-11/6	Test #2	Test #2 Review Questions	Test #2
	The Case of the Cafeteria Calamity - Analyzing and Interpreting your Yeast Experiments
	Poster Teamwork Time		Email Posters to Instructor
Week 11 11/9-11/13	The Case of the Cafeteria Calamity Poster Presentations	Peer Review of Posters	Poster Presentations
	Genetics Teamwork: Assessment of Contributions of Team Members	Assessing the Contributions of Your Team Members Team Evaluation Rubric	Place Poster in Portfolio Oral Communication Skills Folder
	The Case of the Reclusive Relative - Background and Pre-Class Assignment Read: The Case of the Reclusive Relative Background Activity Read Chapter 3, pages 112-118	Reclusive Relative Background Activity	Bring Completed Reclusive Relative Background Activity
	Video: "The Journey of Man"
	Genetics and Diversity: The Genetics of 'Race'. Read: Genetic Variation, Classification and 'Race'	Genetic Variation, Classification and 'Race'	Get Final Diversity Paper Topic

Week 12 11/16-11/20	Genetics Concepts: The Polymerase Chain Reaction and DNA Sequencing Read Text Chapter 20, pages 231-235	PCR and Sequencing Section One Notes	Team Application Problems: Advanced Applications of DNA Sequencing
	The Case of the Reclusive Relative - Amplifying the Mitochondrial Control Region Using PCR	Isolating DNA from Cheek Cells Procedure Amplifying the Mitochondrial Control Region Procedure
	Basic Genetics Concepts: Population Genetics Read: Text Chapter 17, pages 603-615	Population Genetics	RAP 5 Begin Team Application Problems - Population and Evolutionary Genetics
Week 13 11/23-11/27	The Case of the Reclusive Relative - Sequencing the Mitochondrial Control Region	Sequencing Procedure
	Genetics Concepts: The Effect of Sexual Reproduction on Variation Read: Text Chapter 17, pages 615-620		Continue Team Application Problems: Population and Evolutionary Genetics
	Thanksgiving Break Wednesday - Friday
Week 14 11/30-12/4	The Case of the Reclusive Relative - Analyzing Sequence Data
	Genetics Concepts: Sources of Variation - Mutation and Migration Read Chapter 17, pages 620-623	Sources of Variation Section One Handout
	Genetics Concepts: Sources of Variation - Selection and Random Events Read Chapter 17, pages 623-633	Selection and Random Events Section One Handout	Complete Team Application Problems: Population and Evolutionary Genetics
	Genetics and Diversity		Final Diversity Reflection Paper Due as Announced by Professor
Week 15 12/7-12/11	The Case of the Reclusive Relative Poster Presentations Posters cancelled	Peer Review of Posters	Poster Presentations Cancelled
	Genetics Teamwork: Assessment of Contributions of Team Members, Course Assessment	Assessing the Contributions of Your Team Members	Place Poster in Portfolio Oral Communication Skills Folder
	Genetics Concepts: Phylogenetic Analysis and MacClade	Phylogenetic Analysis Using BLAST, CLC, Clustal and MacClade Analysis Mitochondrial FASTA sequences Mitochondrial NBRF Sequences	Team Application Problems - Phyogenetic Analysis and MacClade
Test #3	Test #3 Will Be Held During the Scheduled Final Exam Time	Population Genetics Review Questions Population Genetics Review Answers Molecular Evolution Review Questions Molecular Evolution Review Answers	Test #3